Clinical Data Management

Clinical Data Management is the foundation of reliable clinical research outcomes. Clinovalife delivers structured, technology-driven, and regulator-ready data management solutions that ensure data integrity, compliance, and submission readiness across all phases of clinical development (Phase I–IV).

Clinovalife operates through a risk-based, quality-centric framework aligned with ICH-GCP, FDA, EMA, PMDA and global regulatory expectations.

Study Start-Up & Planning

Data Management Strategy Development

  • Development of Data Management Plan (DMP)
  • Risk-based data review strategy
  • Data flow documentation and oversight
  • Vendor data integration planning

CRF Design & CDASH Alignment

  • CRF design and optimization aligned with CDASH standards
  • eCRF review and sponsor collaboration
  • Metadata-driven CRF libraries
  • Cross-study harmonization strategy

Database Build & Configuration

  • EDC database setup and configuration
  • Edit check specifications and programming
  • User Acceptance Testing (UAT) coordination
  • Role-based access configuration
  • Integration of external data streams

Data Collection & Processing

Data Review & Cleaning

  • Real-time data validation
  • Manual and automated discrepancy detection
  • Query management and tracking
  • Risk-based central data review

Medical Coding

  • MedDRA coding for adverse events
  • WHODrug coding for concomitant medications
  • Coding review and reconciliation

External Data Reconciliation

  • Central lab data reconciliation
  • ECG / Imaging / PK data reconciliation
  • Vendor data integration validation
  • SAE reconciliation with pharmacovigilance

Data Quality & Compliance Oversight

Quality Control & Validation

  • Data validation plan execution
  • Quality control review of critical variables
  • Audit trail review and documentation
  • Compliance monitoring

Risk-Based Data Monitoring

  • Central statistical monitoring
  • Key Risk Indicator (KRI) tracking
  • Data trend analysis
  • Cross-site consistency checks

Regulatory Inspection Readiness

  • Documentation preparation
  • TMF data documentation support
  • Inspection response support
  • Data traceability verification

Database Lock & Study Close-Out

  • Final data cleaning and query resolution
  • Pre-lock quality review
  • Database freeze and lock management
  • Data archival
  • Data transfer to biostatistics and programming teams
  • Submission-ready dataset validation

Technology & Innovation

  • EDC platforms (Medidata, Oracle, Veeva, etc.)
  • Metadata-driven systems (e.g., Oracle DMW)
  • Automated validation checks
  • AI-assisted anomaly detection
  • Real-time dashboard reporting
  • Integration with CDISC standards

Our CDM Value Proposition

  • CDASH-aligned CRF optimization
  • Metadata-driven database architecture
  • Integrated SAE reconciliation processes
  • Risk-based central monitoring
  • Full regulatory inspection readiness
  • Seamless integration with SDTM & ADaM programming